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CuGel

Copper is effective against MRSA, other pathogens and helicobacter, a major cause of gastric ulcers that can often lead to cancerous growths if not treated. Bacteria do not become resistant to copper as is the case with silver and is less toxic than other heavy metal ions. Copper is a natural metal ion in the body (again unlike silver). It is key to a number of processes involved in wound healing including the following:

reduces tissue oxidative damage and activates remodeling
stimulates angiogenesis by induction of growth factors controls copper dependant enzymes (e.g. Lysol oxidase) important in matrix remodeling
controls copper dependant enzymes (e.g. Lysol oxidase) important in matrix remodeling
antiscarring

Different copper salts can be used to produce CuGel including copper acetate and copper chloride. In the current formulation copper sulphate is the preferred and commonly used salt. Copper sulphate is added to the Albigel-P solution at the desired concentration prior to gel formation.

Copper is bound with high affinity at the N-terminus of albumin (NTS) with a number of lower affinity multi-metal binding sites (MBS) available in the albumin and pectin molecules giving good control over copper release rates at the wound site.

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