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CuGel
Copper is effective against MRSA,
other pathogens and helicobacter, a major cause of gastric ulcers
that can often lead to cancerous growths if not treated. Bacteria
do not become resistant to copper as is the case with silver and
is less toxic than other heavy metal ions. Copper is a natural metal
ion in the body (again unlike silver). It is key to a number of processes
involved in wound healing including the following:
• reduces tissue oxidative damage and activates remodeling
• stimulates angiogenesis by induction of growth factors controls
copper dependant enzymes (e.g. Lysol oxidase) important in matrix
remodeling
• controls copper dependant enzymes (e.g. Lysol oxidase) important
in matrix remodeling
• antiscarring
Different copper salts can be used to produce CuGel including copper
acetate and copper chloride. In the current formulation copper sulphate
is the preferred and commonly used salt. Copper sulphate is added
to the Albigel-P solution at the desired concentration prior to gel
formation.
Copper is bound with high affinity at the N-terminus of albumin (NTS)
with a number of lower affinity multi-metal binding sites (MBS) available
in the albumin and pectin molecules giving good control over copper
release rates at the wound site.
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