Technology Chemistry Unique Abilities HSA HSA is produced by the liver and at 55%-60% of the total plasma protein is the most abundant protein in the blood plasma. The greatest impetus to the production and use of HSA as a pure protein for therapeutic purposes came during the World War II with the need for a stable blood substitute (Expander) on the battlefield. HSA has an excellent 60 year record of efficacy and safety - adverse reactions are very rare. Its use as a blood expander has largely been superseded by the use of artificial colloids which are cheaper and more abundant than HSA. However, although an effective substitute as a blood expander artificial colloids cannot provide the other important functions of HSA. HSA has five critical functions within the body: 1. To maintain oncotic pressure between blood vessels and tissues. 2. To transport drugs and metabolites around the body. 3. To detoxify/reprocess substances. 4. To temporarily store molecules. 5. To prevent tissue damage. next >

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